Serine/threonine-protein kinase ULK1 (ULK1) is a 1050-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75385.
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The mean pLDDT of this model is 59.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 28% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 52% |
What pLDDT means and how to read it
Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:25040165, PubMed:39384743). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PubMed:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of…
Interacts with GABARAP and GABARAPL2 (PubMed:11146101). Interacts (via C-terminus) with ATG13 (PubMed:18936157). Part of a complex consisting of ATG13, ATG101, ULK1 and RB1CC1 (PubMed:19287211). Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation (PubMed:19211835,…
Cytoplasm, cytosol, Preautophagosomal structure
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HYO | X-ray | 1.07 Å | A=354-366 |
| 4WNO | X-ray | 1.56 Å | A=1-283 |
| 6MNH | X-ray | 1.73 Å | A=6-290 |
| 5CI7 | X-ray | 1.74 Å | A=1-283 |
| 6QAS | X-ray | 1.75 Å | A/B=1-283 |
| 8P5I | X-ray | 1.83 Å | A/B/C/D=1-283 |
| 8P5L | X-ray | 1.84 Å | A/B=1-283 |
| 4WNP | X-ray | 1.88 Å | A/B/C/D=1-283 |
| 8P5H | X-ray | 1.94 Å | A/B=1-283 |
| 8P5G | X-ray | 2.02 Å | A/B=1-283 |
| 9F32 | X-ray | 2.1 Å | A=1-283 |
| 8P5J | X-ray | 2.16 Å | A/B=1-283 |
| 8P5K | X-ray | 2.21 Å | A/B/C/D=1-283 |
| 8SV9 | X-ray | 2.3 Å | A/B=1-283 |
| 8SOI | EM | 4.2 Å | C=840-1044 |
| 8SRM | EM | 4.46 Å | C/D=836-1050 |
| 8SQZ | EM | 5.85 Å | C/D=836-1050 |
| 9C82 | EM | 6.84 Å | C=442-572 |
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