U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) is a 2136-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O75643.
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The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 42% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (PubMed:35241646). Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30315277, PubMed:30705154, PubMed:30728453). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome
Component of a core complex containing at least PRPF8, SNRNP200, EFTUD2 and SNRNP40. Component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes, building blocks of the spliceosome. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2Q0Z | X-ray | 2.0 Å | X=1808-2136 |
| 8BCE | X-ray | 2.05 Å | B=394-2136 |
| 8BC9 | X-ray | 2.3 Å | B=394-2136 |
| 8BCC | X-ray | 2.35 Å | B=394-2136 |
| 8BCB | X-ray | 2.38 Å | B=394-2136 |
| 6S8Q | X-ray | 2.39 Å | B=394-2136 |
| 8BC8 | X-ray | 2.39 Å | B=394-2136 |
| 8BCG | X-ray | 2.39 Å | B=394-2136 |
| 8BCF | X-ray | 2.42 Å | B=394-2136 |
| 7BDK | X-ray | 2.52 Å | B=394-2136 |
| 7BDJ | X-ray | 2.59 Å | B=394-2136 |
| 6S9I | X-ray | 2.6 Å | B=394-2136 |
| 8H6L | EM | 2.6 Å | 5D=1-2136 |
| 4F92 | X-ray | 2.66 Å | B=402-2125 |
| 7BDL | X-ray | 2.69 Å | B=394-2136 |
| 4F91 | X-ray | 2.7 Å | B=402-2125 |
| 8H6K | EM | 2.7 Å | 5D=1-2136 |
| 5URJ | X-ray | 2.75 Å | A=395-2129 |
| 7OS2 | EM | 2.76 Å | B=395-2129 |
| 5URM | X-ray | 2.8 Å | A/B=395-2129 |
Showing 20 of 79 experimental structures (best resolution first).
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