E3 UFM1-protein ligase 1 (UFL1) is a 794-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O94874.
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The mean pLDDT of this model is 80.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 39% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:27351204, PubMed:30626644, PubMed:30783677, PubMed:32160526, PubMed:32807901, PubMed:35394863, PubMed:36121123, PubMed:36543799, PubMed:36893266, PubMed:37036982, PubMed:37311461, PubMed:37595036, PubMed:37795761, PubMed:38377992, PubMed:38383785, PubMed:38383789). Catalyzes ufmylation of many protein, such as…
Catalytic component of the UFM1 ribosome E3 ligase (UREL) complex, composed of UFL1, DDRGK1 and CDK5RAP3 (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498, PubMed:32160526, PubMed:36121123, PubMed:36543799, PubMed:37595036, PubMed:38383785, PubMed:38383789). Interacts with E2-like enzyme UFC1 (PubMed:20018847, PubMed:30886146, PubMed:37988244, PubMed:38383789). Interacts with…
Endoplasmic reticulum membrane, Cytoplasm, cytosol, Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8QFD | EM | 2.2 Å | s=1-794 |
| 8C0D | X-ray | 2.56 Å | A/D=1-179 |
| 8OJ5 | EM | 2.9 Å | A=1-794 |
| 9GY4 | EM | 3.0 Å | E=1-794 |
| 8B9X | X-ray | 3.07 Å | A/B=27-200 |
| 8OHD | EM | 3.1 Å | A=1-794 |
| 8QFC | EM | 3.2 Å | B=1-794 |
| 8OJ0 | EM | 3.3 Å | A=1-794 |
| 8OJ8 | EM | 3.3 Å | A=1-794 |
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