8OJ8: 60S ribosomal subunit
60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native). Determined by electron microscopy at 3.3 Å resolution. Released 21 Feb 2024.
- Method
- Electron microscopy
- Resolution
- 3.3 Å
- Organism
- Homo sapiens
- Chains
- 50
- Atoms
- 144,625
- Mol. weight
- 2771.6 kDa
- Ligands
- MG, ZN
- Released
- 21 Feb 2024
Explore 8OJ8 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8OJ8 contains 420 α-helices and 341 β-strands across 47 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 1: 22 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-12 | 7 | |
| α-helix | 17-21 | 5 | |
| α-helix | 29-45 | 17 | |
| α-helix | 48-49 | 2 | |
| α-helix | 62-68 | 7 | |
| α-helix | 82-96 | 15 | |
| α-helix | 106-132 | 27 | |
| α-helix | 146-148 | 3 | |
| α-helix | 151-170 | 20 | |
| α-helix | 178-195 | 18 | |
| α-helix | 213-222 | 10 | |
| α-helix | 226-234 | 9 | |
| α-helix | 242-259 | 18 | |
| β-strand | 262 | 1 | 1 |
| β-strand | 263-266 | 4 | 2 |
| β-strand | 267-269 | 3 | 3 |
| β-strand | 278-281 | 4 | 2 |
| α-helix | 285-288 | 4 | |
| α-helix | 289-295 | 7 | |
| α-helix | 297-311 | 15 | |
| α-helix | 340-345 | 6 | |
| α-helix | 358-382 | 25 | |
| α-helix | 387-397 | 11 | |
| β-strand | 399-401 | 3 | 3 |
| α-helix | 407-414 | 8 | |
| α-helix | 417-438 | 22 | |
| α-helix | 447-464 | 18 | |
Chain 2: 2 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-24 | 16 | |
| β-strand | 26 | 1 | 1 |
| α-helix | 30-67 | 38 | |
Chain 3: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 71-94 | 24 | |
Chain A: 27 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 248-264 | 17 | |
| β-strand | 267-268 | 2 | 19 |
| α-helix | 269-275 | 7 | |
| α-helix | 280-287 | 8 | |
| β-strand | 293-295 | 3 | 19 |
| β-strand | 299-302 | 4 | 19 |
| α-helix | 303-319 | 17 | |
| β-strand | 322-324 | 3 | 20 |
| α-helix | 335-346 | 12 | |
| α-helix | 347-349 | 3 | |
| β-strand | 356 | 1 | 20 |
| β-strand | 362-364 | 3 | 20 |
| α-helix | 366-374 | 9 | |
| α-helix | 377-388 | 12 | |
| α-helix | 417-426 | 10 | |
| α-helix | 480-486 | 7 | |
| α-helix | 495-520 | 26 | |
| α-helix | 521-525 | 5 | |
| α-helix | 531-558 | 28 | |
| α-helix | 566-573 | 8 | |
| α-helix | 574-578 | 5 | |
| α-helix | 579-592 | 14 | |
| α-helix | 605-614 | 10 | |
| α-helix | 617-631 | 15 | |
| α-helix | 636-648 | 13 | |
| α-helix | 658-678 | 21 | |
| α-helix | 682-698 | 17 | |
| α-helix | 709-716 | 8 | |
| α-helix | 717-719 | 3 | |
| α-helix | 722-746 | 25 | |
| α-helix | 758-763 | 6 | |
| α-helix | 764-768 | 5 | |
| α-helix | 769-783 | 15 | |
Chain K: 9 helices, 21 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-5 | 4 | 22 |
| α-helix | 13-16 | 4 | |
| β-strand | 17-19 | 3 | 23 |
| β-strand | 24-26 | 3 | 23 |
| α-helix | 32-42 | 11 | |
| β-strand | 48-49 | 2 | 23 |
| β-strand | 53 | 1 | 24 |
| β-strand | 56 | 1 | 24 |
| β-strand | 64-65 | 2 | 25 |
| β-strand | 69-72 | 4 | 25 |
| α-helix | 78-87 | 10 | |
| β-strand | 93-96 | 4 | 25 |
| α-helix | 104-107 | 4 | |
| β-strand | 108-110 | 3 | 26 |
| β-strand | 114-117 | 4 | 26 |
| α-helix | 123-133 | 11 | |
| β-strand | 136-139 | 4 | 26 |
| β-strand | 142 | 1 | 27 |
| β-strand | 145 | 1 | 27 |
| α-helix | 148-151 | 4 | |
| β-strand | 153-154 | 2 | 28 |
| β-strand | 159-161 | 3 | 28 |
| α-helix | 167-177 | 11 | |
| β-strand | 181-183 | 3 | 28 |
| β-strand | 186 | 1 | 29 |
| β-strand | 190 | 1 | 29 |
| α-helix | 193-196 | 4 | |
| β-strand | 198-199 | 2 | 22 |
| β-strand | 204-207 | 4 | 22 |
| α-helix | 212-222 | 11 | |
Chain La: 8 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-10 | 4 | |
| α-helix | 42-48 | 7 | |
| α-helix | 65-68 | 4 | |
| β-strand | 72-74 | 3 | 30 |
| α-helix | 78-81 | 4 | |
| α-helix | 84-92 | 9 | |
| β-strand | 97-98 | 2 | 89 |
| β-strand | 100-102 | 3 | 31 |
| α-helix | 103-106 | 4 | |
| β-strand | 110-112 | 3 | 30 |
| β-strand | 123-126 | 4 | 31 |
| β-strand | 128-129 | 2 | 30 |
| α-helix | 131-140 | 10 | |
| β-strand | 143-146 | 4 | 31 |
Chain LA: 10 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-5 | 2 | |
| α-helix | 14-16 | 3 | |
| α-helix | 29-32 | 4 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 32 |
| α-helix | 57 | 1 | |
| β-strand | 58-64 | 7 | 32 |
| β-strand | 71-77 | 7 | 32 |
| β-strand | 79 | 1 | 33 |
| β-strand | 83 | 1 | 34 |
| β-strand | 87-91 | 5 | 32 |
| β-strand | 101-103 | 3 | 32 |
| α-helix | 108 | 1 | |
| β-strand | 112-114 | 3 | 32 |
| β-strand | 116 | 1 | 35 |
| β-strand | 126 | 1 | 35 |
| β-strand | 134-140 | 7 | 32 |
| β-strand | 145-149 | 5 | 32 |
| β-strand | 155-159 | 5 | 32 |
| β-strand | 163-166 | 4 | 32 |
| β-strand | 169 | 1 | 33 |
| β-strand | 171 | 1 | 36 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-190 | 9 | |
| α-helix | 206-208 | 3 | |
| β-strand | 225 | 1 | 37 |
| α-helix | 229-230 | 2 | |
| β-strand | 238 | 1 | 37 |
Chain Lb: 7 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-18 | 7 | |
| α-helix | 22-25 | 4 | |
| α-helix | 37-49 | 13 | |
| α-helix | 50-53 | 4 | |
| α-helix | 54-74 | 21 | |
| α-helix | 92-100 | 9 | |
| α-helix | 106-117 | 12 | |
39 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Protein transport protein Sec61 subunit alpha isoform 1 | 1 | protein | 476 | Homo sapiens | P38377 (AlphaFold model) |
| Protein transport protein Sec61 subunit gamma | 2 | protein | 68 | Homo sapiens | P60059 (AlphaFold model) |
| Protein transport protein Sec61 subunit beta | 3 | protein | 96 | Homo sapiens | P60468 (AlphaFold model) |
| 28S rRNA | 5 | RNA | 5070 | Homo sapiens | |
| 5S rRNA | 7 | RNA | 121 | Homo sapiens | |
| 5.8S rRNA | 8 | RNA | 157 | Homo sapiens | |
| E3 UFM1-protein ligase 1 | A | protein | 794 | Homo sapiens | O94874 (AlphaFold model) |
| Eukaryotic translation initiation factor 6 | K | protein | 245 | Homo sapiens | P56537 |
| 60S ribosomal protein L8 | LA | protein | 257 | Homo sapiens | P62917 |
| 60S ribosomal protein L3 | LB | protein | 403 | Homo sapiens | P39023 |
| 60S ribosomal protein L4 | LC | protein | 427 | Homo sapiens | P36578 |
| 60S ribosomal protein L5 | LD | protein | 297 | Homo sapiens | P46777 |
38 more molecules are not listed.
Sequence of entity 1 (1), FASTA
>8OJ8_1 Protein transport protein Sec61 subunit alpha isoform 1 (chains 1)
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSAD
PFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFG
MIITIGQSIVYVMTGMYGDPSEMGSGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGIS
LFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLP
NLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSN
LYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLSPPESFGSVLEDPVH
AVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTA
AAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
Sequence of entity 2 (2), FASTA
>8OJ8_2 Protein transport protein Sec61 subunit gamma (chains 2)
MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIP
INNIIVGG
Sequence of entity 3 (3), FASTA
>8OJ8_3 Protein transport protein Sec61 subunit beta (chains 3)
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYT
EDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
Sequence of entity 4 (5), FASTA
>8OJ8_4 28S rRNA (chains 5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGCCCGGCGGAUCUUUCCCGCCCCCCGUUCCUCCCGACCCCU
CCACCCGCCCUCCCUUCCCCCGCCGCCCCUCCUCCUCCUCCCCGGAGGGGGCGGGCUCCG
GCGGGUGCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGA
CCGGCGACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCG
GGACGGCUGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGCCCCGUCCGUCCGUCCGUC
CGUCCUCCUCCUCCCCCGUCUCCGCCCCCCGGCCCCGCGUCCUCCCUCGGGAGGGCGCGC
GGGUCGGGGCGGCGGCGGCGGCGGCGGUGGCGGCGGCGGCGGCGGCGGCGGGACCGAAAC
CCCCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAUCCCGGGGCCGAGGGA
GCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCCCACCCCCGCGGGGAAUCCCCCG
CGAGGGGGGUCUCCCCCGCGGGGGCGCGCCGGCGUCUCCUCGUGGGGGGGCCGGGCCACC
CCUCCCACGGCGCGACCGCUCUCCCACCCCUCCUCCCCGCGCCCCCGCCCCGGCGACGGG
GGGGGUGCCGCGCGCGGGUCGGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGGCGGG
UCGCGCCGUCGGGCCCGGGGGAGGUUCUCUCGGGGCCACGCGCGCGUCCCCCGAAGAGGG
GGACGGCGGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUU
GAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCG
UGGCGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCU
CCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCA
CGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGA
GGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAG
GAUAGCUGGCGCUCUCGCAGACCCGACGCACCCCCGCCACGCAGUUUUAUCCGGUAAAGC
GAAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGU
AAGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACU
UUUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGC
CGACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAU
GGAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGA
AAAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGA
CGGGAGCGGCGGCGGCGGCGCGCGCGCGCGCGCGUGUGGUGUGCGUCGGAGGGCGGCGGC
GGCGGCGGCGGCGGGGGUGUGGGGUCCUUCCCCCGCCCCCCCCCCCACGCCUCCUCCCCU
CCUCCCGCCCACGCCCCGCUCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAG
UAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGC
AGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGG
AGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGA
GCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUC
GGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGU
AACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUG
AAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCG
UCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGG
UGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUC
UGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAU
AAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGC
GCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCACCCCCCUCGCGGCCC
UCCCCCGCCCCACCCCGCGCGCGCCGCUCGCUCCCUCCCCGCCCCGCGCCCUCUCUCUCU
CUCUCUCCCCCGCUCCCCGUCCUCCCCCCUCCCCGGGGGAGCGCCGCGUGGGGGCGGCGG
CGGGGGGAGAAGGGUCGGGGCGGCAGGGGCCGGCGGCGGCCCGCCGCGGGGCCCCGGCGG
CGGGGGCACGGUCCCCCGCGAGGGGGGCCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGA
CUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCC
GCCCCCGGGGAGCCCGGCGGGCGCCGGCGCGCCCCCCCCCCCACCCCACGUCUCGUCGCG
CGCGCGUCCGCUGGGGGCGGGGAGCGGUCGGGCGGCGGCGGUCGGCGGGCGGCGGGGCGG
GGCGGUUCGUCCCCCCGCCCUACCCCCCCGGCCCCGUCCGCCCCCCGUUCCCCCCUCCUC
CUCGGCGCGCGGCGGCGGCGGCGGCAGGCGGCGGAGGGGCCGCGGGCCGGUCCCCCCCGC
CGGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAG
CCGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGC
GAAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAG
UGAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAG
CCAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGU
CCCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGG
AAAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUA
GAAUAAGUGGGAGGCCCCCGGCGCCCCCCCGGUGUCCCCGCGAGGGGCCCGGGGCGGGGU
CCGCCGGCCCUGCGGGCCGCCGGUGAAAUACCACUACUCUGAUCGUUUUUUCACUGACCC
GGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGC
GCGCCGGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCG
GUACACCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCU
CCCGUGGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCG
UGAAAGCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAA
AGUUACCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUG
AUCCUUCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGU
UCACCCACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUAC
CCUACUGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUU
CAGACAUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGG
AUUAUGACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCG
CGGAGCCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCUGUCCCCGCCGGCGGGCCGCCC
CCCCCCUCCACGCGCCCCGCGCGCGCGGGAGGGCGCGUGCCCCGCCGCGCGCCGGGACCG
GGGUCCGGUGCGGAGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCUGGAAAGGCGGCCGC
CCCCUCGCCCGUCACGCACCGCACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGAC
GACCUGCUUCUGGGUCGGGG
Sequence of entity 5 (7), FASTA
>8OJ8_5 5S rRNA (chains 7)
GUCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGG
GUCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
U
Sequence of entity 6 (8), FASTA
>8OJ8_6 5.8S rRNA (chains 8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUU
Sequence of entity 7 (A), FASTA
>8OJ8_7 E3 UFM1-protein ligase 1 (chains A)
MADAWEEIRRLAADFQRAQFAEATQRLSERNCIEIVNKLIAQKQLEVVHTLDGKEYITPA
QISKEMRDELHVRGGRVNIVDLQQVINVDLIHIENRIGDIIKSEKHVQLVLGQLIDENYL
DRLAEEVNDKLQESGQVTISELCKTYDLPGNFLTQALTQRLGRIISGHIDLDNRGVIFTE
AFVARHKARIRGLFSAITRPTAVNSLISKYGFQEQLLYSVLEELVNSGRLRGTVVGGRQD
KAVFVPDIYSRTQSTWVDSFFRQNGYLEFDALSRLGIPDAVSYIKKRYKTTQLLFLKAAC
VGQGLVDQVEASVEEAISSGTWVDIAPLLPTSLSVEDAAILLQQVMRAFSKQASTVVFSD
TVVVSEKFINDCTELFRELMHQKAEKEMKNNPVHLITEEDLKQISTLESVSTSKKDKKDE
RRRKATEGSGSMRGGGGGNAREYKIKKVKKKGRKDDDSDDESQSSHTGKKKPEISFMFQD
EIEDFLRKHIQDAPEEFISELAEYLIKPLNKTYLEVVRSVFMSSTTSASGTGRKRTIKDL
QEEVSNLYNNIRLFEKGMKFFADDTQAALTKHLLKSVCTDITNLIFNFLASDLMMAVDDP
AAITSEIRKKILSKLSEETKVALTKLHNSLNEKSIEDFISCLDSAAEACDIMVKRGDKKR
ERQILFQHRQALAEQLKVTEDPALILHLTSVLLFQFSTHSMLHAPGRCVPQIIAFLNSKI
PEDQHALLVKYQGLVVKQLVSQSKKTGQGDYPLNNELDKEQEDVASTTRKELQELSSSIK
DLVLKSRKSSVTEE
Sequence of entity 8 (K), FASTA
>8OJ8_8 Eukaryotic translation initiation factor 6 (chains K)
MAVRASFENNCEIGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIG
RMCVGNRHGLLVPNNTTDQELQHIRNSLPDTVQIRRVEERLSALGNVTTCNDYVALVHPD
LDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVP
LVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAQPSTIATSMRDSL
IDSLT
Sequence of entity 9 (LA), FASTA
>8OJ8_9 60S ribosomal protein L8 (chains LA)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN
Sequence of entity 10 (LB), FASTA
>8OJ8_10 60S ribosomal protein L3 (chains LB)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 11 (LC), FASTA
>8OJ8_11 60S ribosomal protein L4 (chains LC)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKL
APGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAAAAA
LQAKSDEKAAVAGKKPVVGKKGKKAAVGVKKQKKPLVGKKAAATKKPAPEKKPAEKKPTT
EEKKPAA
Sequence of entity 12 (LD), FASTA
>8OJ8_12 60S ribosomal protein L5 (chains LD)
MGFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMY
KKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 220 |
| ZN | Zinc ion | Zn | 5 |
Primary citation
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER. DaRosa, P.A., Penchev, I., Gumbin, S.C. et al. Nature (2024) 627:445-452. DOI 10.1038/s41586-024-07073-0 · PubMed
Other PDB entries of the same protein (UniProt P38377 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 6Z3T 2.69 Å, Structure of canine Sec61 inhibited by mycolactone
- 8RJB 2.69 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
- 8RJD 2.79 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
- 8RJC 2.9 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in…
- 7TM3 3.25 Å, Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in…
- 8BTK 3.5 Å, Structure of the TRAP complex with the Sec translocon and a translating ribosome
- 3JC2 3.6 Å, The structure of the mammalian Sec61 channel opened by a signal sequence
- 7TUT 3.88 Å, Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in…
- 6R7Q 3.9 Å, Structure of XBP1u-paused ribosome nascent chain complex with Sec61.
- 6FTI 4.2 Å, Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the…
- 6FTJ 4.7 Å, Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the…
- 2WWB 6.48 Å, cryo-EM structure of the mammalian SEC61 complex bound to the actively translating wheat…
Browse structure collections
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