Zinc finger protein SNAI1 (SNAI1) is a 264-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: O95863.
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The mean pLDDT of this model is 57.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 37% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed…
Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains) (PubMed:18331720). Interacts with LOXL2 and LOXL3 (PubMed:16096638). Interacts with EGR1 upon TPA induction (PubMed:20121949). Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import (PubMed:15836774,…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4QLI | X-ray | 1.45 Å | B=175-180 |
| 3W5K | X-ray | 2.6 Å | B=1-264 |
| 8F59 | X-ray | 2.8 Å | C=2-10 |
| 8FJ7 | X-ray | 2.8 Å | C=2-10 |
| 8BOX | X-ray | 2.82 Å | C=2-10 |
| 8FDV | X-ray | 2.95 Å | C=2-10 |
| 2Y48 | X-ray | 3.0 Å | C=2-21 |
| 3ZMT | X-ray | 3.1 Å | C=2-7 |
| 8ULZ | X-ray | 3.32 Å | C=2-10 |
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