L-lactate dehydrogenase (cytochrome) (CYB2) is a 591-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00175.
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The mean pLDDT of this model is 85.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c (PubMed:11914072). Is involved in the utilization of (S)-lactate as a sole source of carbon for growth (PubMed:3004948). Can also use ferricyanide as an electron acceptor in vitro (PubMed:3004948, PubMed:4593578)
Homotetramer
Mitochondrion intermembrane space
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1KBI | X-ray | 2.3 Å | A/B=81-591 |
| 1FCB | X-ray | 2.4 Å | A/B=81-591 |
| 1KBJ | X-ray | 2.5 Å | A/B=180-591 |
| 1LTD | X-ray | 2.6 Å | A/B=86-591 |
| 1SZF | X-ray | 2.7 Å | A/B=81-591 |
| 1SZG | X-ray | 2.7 Å | A/B=81-591 |
| 3KS0 | X-ray | 2.7 Å | A/B=86-180 |
| 1QCW | X-ray | 2.75 Å | A/B=182-591 |
| 2OZ0 | X-ray | 2.8 Å | A/B=81-591 |
| 1LCO | X-ray | 2.9 Å | A/B=81-591 |
| 1LDC | X-ray | 2.9 Å | A/B=81-591 |
| 1SZE | X-ray | 3.0 Å | A/B=81-591 |
| 9J9B | EM | 3.83 Å | C=121-167 |
| 8HCO | EM | 4.1 Å | G=32-125 |
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