Phenylalanine-4-hydroxylase (PAH) is a 452-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00439.
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The mean pLDDT of this model is 88.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 62% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine
Homodimer and homotetramer
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1J8U | X-ray | 1.5 Å | A=103-427 |
| 6HPO | X-ray | 1.67 Å | A=1-452 |
| 1J8T | X-ray | 1.7 Å | A=103-427 |
| 5FII | X-ray | 1.8 Å | A/B/C/D=19-118 |
| 1DMW | X-ray | 2.0 Å | A=118-424 |
| 1MMK | X-ray | 2.0 Å | A=103-427 |
| 1MMT | X-ray | 2.0 Å | A=103-427 |
| 1PAH | X-ray | 2.0 Å | A=117-424 |
| 3PAH | X-ray | 2.0 Å | A=117-424 |
| 4PAH | X-ray | 2.0 Å | A=117-424 |
| 1LRM | X-ray | 2.1 Å | A=103-427 |
| 1TDW | X-ray | 2.1 Å | A=117-424 |
| 5PAH | X-ray | 2.1 Å | A=117-424 |
| 4ANP | X-ray | 2.11 Å | A=104-427 |
| 6PAH | X-ray | 2.15 Å | A=117-424 |
| 1TG2 | X-ray | 2.2 Å | A=117-424 |
| 1KW0 | X-ray | 2.5 Å | A=103-427 |
| 6N1K | X-ray | 3.06 Å | A/B/C/D=2-452 |
| 2PAH | X-ray | 3.1 Å | A/B=118-452 |
| 6HYC | X-ray | 3.18 Å | A/B/C/D=1-452 |
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