Complement factor D (CFD) is a 253-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00746.
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The mean pLDDT of this model is 91.0 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324, PubMed:9748277). In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3 (PubMed:21205667, PubMed:22362762, PubMed:6769474, PubMed:874324). The alternative complement pathway acts as an amplification loop that enhances complement…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NAT | X-ray | 1.17 Å | A=26-253 |
| 2XW9 | X-ray | 1.2 Å | A=26-253 |
| 5NAW | X-ray | 1.25 Å | A=26-253 |
| 5MT0 | X-ray | 1.29 Å | A=26-253 |
| 5NB7 | X-ray | 1.33 Å | A=26-253 |
| 6FUH | X-ray | 1.37 Å | A=26-253 |
| 6FUI | X-ray | 1.38 Å | A=26-253 |
| 5FBE | X-ray | 1.43 Å | A=26-253 |
| 5FBI | X-ray | 1.47 Å | A=26-253 |
| 1BIO | X-ray | 1.5 Å | A=26-253 |
| 6FUT | X-ray | 1.5 Å | A=26-253 |
| 5NAR | X-ray | 1.55 Å | A=26-253 |
| 5MT4 | X-ray | 1.65 Å | A=26-253 |
| 6FTY | X-ray | 1.67 Å | A=26-253 |
| 6FTZ | X-ray | 1.67 Å | A=26-253 |
| 5NB6 | X-ray | 1.75 Å | A=26-253 |
| 1DIC | X-ray | 1.8 Å | A=26-253 |
| 4CBN | X-ray | 1.8 Å | A/B=26-253 |
| 4CBO | X-ray | 1.8 Å | A/B=26-253 |
| 6QMT | X-ray | 1.8 Å | A/B=2-253 |
Showing 20 of 40 experimental structures (best resolution first).
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