Renin (REN) is a 406-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00797.
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The mean pLDDT of this model is 85.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 65% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney
Interacts with ATP6AP2
Secreted, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3K1W | X-ray | 1.5 Å | A/B=67-406 |
| 1HRN | X-ray | 1.8 Å | A/B=70-406 |
| 2G24 | X-ray | 1.9 Å | A/B=74-406 |
| 2IKO | X-ray | 1.9 Å | A/B=67-406 |
| 3G72 | X-ray | 1.9 Å | A/B=67-406 |
| 3KM4 | X-ray | 1.9 Å | A/B=70-406 |
| 3G6Z | X-ray | 2.0 Å | A/B=67-406 |
| 3G70 | X-ray | 2.0 Å | A/B=67-406 |
| 3GW5 | X-ray | 2.0 Å | A/B=70-406 |
| 3OWN | X-ray | 2.0 Å | A/B=67-406 |
| 4Q1N | X-ray | 2.09 Å | A/B=67-406 |
| 2G26 | X-ray | 2.1 Å | A/B=74-406 |
| 3SFC | X-ray | 2.1 Å | A/B=67-406 |
| 4S1G | X-ray | 2.1 Å | A/B=67-406 |
| 5KOT | X-ray | 2.1 Å | A/B=70-406 |
| 5SXN | X-ray | 2.1 Å | A/B=68-406 |
| 7XGO | X-ray | 2.1 Å | A/B=67-406 |
| 3Q5H | X-ray | 2.16 Å | A/B=67-406 |
| 3OAD | X-ray | 2.17 Å | A/C=67-232, B/D=237-406 |
| 3Q4B | X-ray | 2.19 Å | A/B=67-406 |
Showing 20 of 91 experimental structures (best resolution first).
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