Carbonic anhydrase 2 (CA2) is a 260-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P00918.
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The mean pLDDT of this model is 97.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 99% |
| 70 to 90 | Confident: backbone generally right | 0% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834,…
Interacts with SLC4A4 (PubMed:14567693, PubMed:15218065). Interaction with SLC4A7 regulates SLC4A7 transporter activity (PubMed:14736710). Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain) (PubMed:15990874)
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3K34 | X-ray | 0.9 Å | A=1-260 |
| 3KS3 | X-ray | 0.9 Å | A=1-260 |
| 5Y2S | X-ray | 0.9 Å | A=1-260 |
| 6B00 | X-ray | 0.9 Å | A=3-260 |
| 6KLZ | X-ray | 0.9 Å | A=1-260 |
| 6KM2 | X-ray | 0.9 Å | A=1-260 |
| 3U7C | X-ray | 0.93 Å | A=1-260 |
| 6KM0 | X-ray | 0.93 Å | A=1-260 |
| 6ROB | X-ray | 0.93 Å | A=1-260 |
| 6ROE | X-ray | 0.94 Å | A=1-260 |
| 6SBL | X-ray | 0.94 Å | A=1-260 |
| 1LUG | X-ray | 0.95 Å | A=2-260 |
| 6RH4 | X-ray | 0.95 Å | A=1-260 |
| 6RQI | X-ray | 0.95 Å | A=1-260 |
| 6S9Z | X-ray | 0.95 Å | A=1-260 |
| 6SAY | X-ray | 0.95 Å | A=1-260 |
| 6SBH | X-ray | 0.95 Å | A=1-260 |
| 6SBM | X-ray | 0.95 Å | A=1-260 |
| 6YZN | X-ray | 0.95 Å | A=1-260 |
| 4YXI | X-ray | 0.96 Å | A=1-260 |
Showing 20 of 1200 experimental structures (best resolution first).
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