Alpha-1-antitrypsin (SERPINA1) is a 418-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01009.
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The mean pLDDT of this model is 88.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin
Interacts with CELA2A (PubMed:31358993). Interacts with ERGIC3 and LMAN1/ERGIC53 (PubMed:31142615). Interacts with PRSS1/trypsin (PubMed:11057674). Interacts with PRSS1/Trypsin (PubMed:11057674). The variants S and Z interact with CANX and PDIA3 (PubMed:23826168)
Secreted, Endoplasmic reticulum, Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8PI2 | X-ray | 1.48 Å | A=26-418 |
| 3NDD | X-ray | 1.5 Å | A=46-382, B=383-418 |
| 6I7U | X-ray | 1.55 Å | A=26-418 |
| 5NBU | X-ray | 1.67 Å | A=43-418 |
| 8QZ5 | X-ray | 1.69 Å | A=26-418 |
| 5NBV | X-ray | 1.73 Å | A=43-418 |
| 7AEL | X-ray | 1.76 Å | AAA=26-418 |
| 6I4V | X-ray | 1.78 Å | A=26-418 |
| 3NE4 | X-ray | 1.81 Å | A=48-418 |
| 7NPL | X-ray | 1.82 Å | A=26-418 |
| 7NPK | X-ray | 1.83 Å | A=26-417 |
| 9GGP | X-ray | 1.84 Å | A/B=26-418 |
| 6ROD | X-ray | 1.85 Å | A=26-418 |
| 6IAY | X-ray | 1.9 Å | A=26-418 |
| 4PYW | X-ray | 1.91 Å | A=26-418 |
| 8P4J | X-ray | 1.91 Å | A=26-418 |
| 8R13 | X-ray | 1.95 Å | A=26-418 |
| 1QLP | X-ray | 2.0 Å | A=26-418 |
| 2QUG | X-ray | 2.0 Å | A=25-418 |
| 1HP7 | X-ray | 2.1 Å | A=25-418 |
Showing 20 of 46 experimental structures (best resolution first).
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