Angiotensinogen (AGT) is a 476-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01019.
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The mean pLDDT of this model is 86.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis
During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 and as a complex (probably a 2:2:2 heterohexamer) with pro-PRG2 and C3dg
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5NJ9 | X-ray | 1.25 Å | E/F=25-28 |
| 3WOO | X-ray | 1.8 Å | C/D=27-32 |
| 4AA1 | X-ray | 1.99 Å | P=25-32 |
| 4APH | X-ray | 1.99 Å | P=25-32 |
| 4FYS | X-ray | 2.01 Å | C=27-32 |
| 3WOR | X-ray | 2.1 Å | C/D=25-32 |
| 5M3Y | X-ray | 2.3 Å | A=25-476 |
| 5E2Q | X-ray | 2.4 Å | B=25-32 |
| 6I3F | X-ray | 2.55 Å | A=25-476 |
| 5M3X | X-ray | 2.63 Å | A/B=35-476 |
| 6OS0 | X-ray | 2.9 Å | B=25-32 |
| 6I3I | X-ray | 2.97 Å | A=25-476 |
| 3CK0 | X-ray | 3.0 Å | P=25-32 |
| 5XJM | X-ray | 3.2 Å | B=26-31 |
| 6JOD | X-ray | 3.2 Å | B=25-32 |
| 2WXW | X-ray | 3.3 Å | A=25-476 |
| 7C6A | X-ray | 3.4 Å | B=26-31 |
| 2X0B | X-ray | 4.33 Å | B/D/F/H=25-476 |
| 1N9U | NMR | A=25-34 | |
| 1N9V | NMR | A=25-32 |
Showing 20 of 21 experimental structures (best resolution first).
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