GTPase HRas (HRAS) is a 189-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01112.
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The mean pLDDT of this model is 91.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300)
In its GTP-bound form interacts with PLCE1 (PubMed:11022048). Interacts with TBC1D10C (PubMed:17230191). Interacts with RGL3 (By similarity). Interacts with HSPD1 (By similarity). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14 (By similarity). Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ…
Cell membrane, Golgi apparatus, Golgi apparatus membrane, Nucleus, Cytoplasm, Cytoplasm, perinuclear region
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2CE2 | X-ray | 1.0 Å | X=1-166 |
| 2EVW | X-ray | 1.05 Å | X=1-166 |
| 8TBG | X-ray | 1.2 Å | A/B=1-166 |
| 2CLD | X-ray | 1.22 Å | X=1-166 |
| 2CL6 | X-ray | 1.24 Å | X=1-166 |
| 2CL7 | X-ray | 1.25 Å | X=1-166 |
| 5WDQ | X-ray | 1.25 Å | A=1-166 |
| 1CTQ | X-ray | 1.26 Å | A=1-166 |
| 2CLC | X-ray | 1.3 Å | X=1-166 |
| 3K8Y | X-ray | 1.3 Å | A=1-166 |
| 3OIW | X-ray | 1.3 Å | A=1-166 |
| 3TGP | X-ray | 1.31 Å | A=1-166 |
| 3OIU | X-ray | 1.32 Å | A=1-166 |
| 4DLR | X-ray | 1.32 Å | A=1-166 |
| 8BWG | X-ray | 1.32 Å | R=1-166 |
| 2RGB | X-ray | 1.35 Å | A=1-166 |
| 5P21 | X-ray | 1.35 Å | A=1-166 |
| 5WDP | X-ray | 1.35 Å | A=1-166 |
| 8CNJ | X-ray | 1.35 Å | A/B=1-166 |
| 3I3S | X-ray | 1.36 Å | R=1-166 |
Showing 20 of 245 experimental structures (best resolution first).
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