Pro-epidermal growth factor (EGF) is a 1207-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01133.
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The mean pLDDT of this model is 70.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 20% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941)
Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD)
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1NQL | X-ray | 2.8 Å | B=971-1023 |
| 1JL9 | X-ray | 3.0 Å | A/B=971-1021 |
| 7SYD | EM | 3.1 Å | C/D=971-1023 |
| 1IVO | X-ray | 3.3 Å | C/D=971-1023 |
| 3NJP | X-ray | 3.3 Å | C/D=975-1021 |
| 7SYE | EM | 3.3 Å | C/D=971-1023 |
| 7SZ0 | EM | 3.3 Å | C/D=971-1023 |
| 8HGO | EM | 3.31 Å | C=971-1023 |
| 7SZ1 | EM | 3.4 Å | C/D=971-1023 |
| 8HGS | EM | 3.81 Å | C/D=971-1023 |
| 7OM4 | X-ray | 6.05 Å | C=971-1023 |
| 1P9J | NMR | A=974-1022 | |
| 2KV4 | NMR | A=971-1023 |
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