Insulin (INS) is a 110-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01308.
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The mean pLDDT of this model is 52.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 36% |
| Below 50 | Very low: often disordered regions | 51% |
What pLDDT means and how to read it
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Heterodimer of a B chain and an A chain linked by two disulfide bonds (PubMed:25423173)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3W7Y | X-ray | 0.92 Å | A/C=90-110, B/D=25-54 |
| 5E7W | X-ray | 0.95 Å | A/C=90-110, B/D=25-54 |
| 5HQI | X-ray | 0.97 Å | A=90-110, B=25-54 |
| 1MSO | X-ray | 1.0 Å | A/C=90-110, B/D=25-54 |
| 3HYD | X-ray | 1.0 Å | A=35-41 |
| 6VER | X-ray | 1.05 Å | A=90-110, B=25-46 |
| 4FKA | X-ray | 1.08 Å | A/C=90-110, B/D=25-54 |
| 3TT8 | X-ray | 1.12 Å | A/C=90-110, B/D=25-54 |
| 3W7Z | X-ray | 1.15 Å | A/C=90-110, B/D=25-54 |
| 5UOZ | X-ray | 1.17 Å | A=90-110, B=25-54 |
| 5USP | X-ray | 1.17 Å | A=90-110, B=25-54 |
| 8OKY | X-ray | 1.17 Å | A=90-110, B=25-50 |
| 5URT | X-ray | 1.18 Å | A=90-110, B=25-54 |
| 1G7A | X-ray | 1.2 Å | A/C/E/G=90-110, B/D/F/H=25-54 |
| 4AJX | X-ray | 1.2 Å | A/C/E/G/I/K=90-110, B/D/F/H/J/L=25-53 |
| 7QGF | X-ray | 1.2 Å | AAA=90-110, BBB=25-53 |
| 5UU2 | X-ray | 1.22 Å | A=90-110, B=25-54 |
| 7RKD | X-ray | 1.25 Å | A/C=90-110, B/D=25-54 |
| 8PI4 | X-ray | 1.25 Å | A=25-53, A=90-110 |
| 6GV0 | X-ray | 1.26 Å | B/D=25-54, G/I=90-110 |
Showing 20 of 382 experimental structures (best resolution first).
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