Alpha-mammal toxin AaH2 is a 85-residue protein from Androctonus australis. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01484.
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The mean pLDDT of this model is 91.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 73% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Alpha toxin that binds voltage-independently at site-3 of sodium channels (Nav), inhibits the inactivation of the activated channels, and weakly inhibits activation, thereby blocking neuronal transmission. Inserts into voltage-sensing domain IV to stabilize a deactivated state, thereby preventing fast-inactivation (PubMed:30733386). Principally slows the inactivation process of TTX-sensitive sodium channels (PubMed:23685008). It is active on mammalian brain Nav1.2/SCN2A (EC(50)human=0.72 nM, EC(50)rat=2.6 nM), on rat skeletal muscle Nav1.4/SCN4A (EC(50)=2.2 nM) (PubMed:12911331), and on human neuronal Nav1.7/SCN9A (EC(50)=6.8-51.7 nM) (PubMed:23685008, PubMed:30733386). In vivo,…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1AHO | X-ray | 0.96 Å | A=20-83 |
| 1PTX | X-ray | 1.3 Å | A=20-83 |
| 1SEG | X-ray | 1.3 Å | A=20-83 |
| 4AEI | X-ray | 2.3 Å | A/B/C=20-83 |
| 6NT4 | EM | 3.5 Å | B/C=20-83 |
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