Immunoglobulin heavy constant gamma 3 (IGHG3) is a 446-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P01860.
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The mean pLDDT of this model is 82.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Constant region of immunoglobulin (Ig) heavy chains. Igs are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors, which upon binding to a specific antigen trigger the clonal expansion and differentiation of B lymphocytes into Ig-secreting plasma cells. Secreted Igs known as antibodies mediate the effector phase of humoral immunity by blocking the interaction of infectious antigens with cellular receptors (via the antigen-binding region) and eliciting effector mechanisms that lead to pathogen neutralization (via the constant region) (PubMed:17576170, PubMed:20176268, PubMed:22158414). The…
Immunoglobulins (Igs) are composed of two identical heavy chains and two identical light chains; disulfide-linked. Assembled in immune complexes interacts (via Fc region and its N-linked glycan) with Fc receptors. Interacts with FCGR1A, FCGR2A, FCGR2B, FCGR3A and FCGR3B; these interactions are impacted by the glycans attached on the Fc domain, with afucosylated glycans displaying higher affinity…
Secreted, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5W38 | X-ray | 1.8 Å | A/B=155-375 |
| 6G1E | X-ray | 1.88 Å | A=204-375 |
| 5M3V | X-ray | 1.97 Å | A=286-375 |
| 4ZNC | X-ray | 2.28 Å | D/E/F=168-375 |
| 4WWI | X-ray | 2.31 Å | D/E/F=168-375 |
| 6D58 | X-ray | 2.39 Å | A/B=164-375 |
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