Histone H2B (His2B) is a 123-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02283.
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The mean pLDDT of this model is 84.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in recruitment of Parp1 to chromatin and regulates its activity; inhibits DNA-dependent activation of Parp1 (PubMed:17827147)
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with Parp1 (via C-terminus); the interaction is direct and regulates Parp1 enzymatic reaction (PubMed:17827147)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CVE | X-ray | 1.5 Å | D/E=3-10 |
| 9ZQB | EM | 2.1 Å | C/D=2-123 |
| 2NQB | X-ray | 2.3 Å | D/H=2-123 |
| 9ZQC | EM | 2.37 Å | C/D=2-123 |
| 2PYO | X-ray | 2.43 Å | D/H=2-123 |
| 8UX1 | EM | 2.5 Å | D/H=2-123 |
| 8PP7 | EM | 2.91 Å | D/H=1-123 |
| 6DZT | EM | 2.99 Å | D/H=2-123 |
| 8PP6 | EM | 3.18 Å | D/H=2-123 |
| 9ZQA | EM | 3.28 Å | C/D=2-123 |
| 9MU4 | EM | 3.29 Å | d/h=27-123 |
| 9ZQ9 | EM | 3.3 Å | C/D=2-123 |
| 4QLC | X-ray | 3.5 Å | D/H=2-123 |
| 4X23 | X-ray | 3.5 Å | D/H/N/R=33-122 |
| 6PWE | EM | 3.95 Å | D/H=1-123 |
| 6PWF | EM | 4.07 Å | D/H=1-123 |
| 7XYF | EM | 4.3 Å | D/H=29-123 |
| 7XYG | EM | 5.4 Å | D/H=1-123 |
| 5WCU | X-ray | 5.53 Å | D/H/N/R=29-122 |
| 9MU5 | EM | 6.3 Å | h=27-123 |
Showing 20 of 22 experimental structures (best resolution first).
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