Collagen alpha-1(I) chain (COL1A1) is a 1464-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02452.
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The mean pLDDT of this model is 52.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 67% |
What pLDDT means and how to read it
Type I collagen is a member of group I collagen (fibrillar forming collagen)
Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity). Interacts with TRAM2 (PubMed:14749390). Interacts with MFAP4 in a Ca (2+)-dependent manner (By similarity)
Secreted, extracellular space, extracellular matrix
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5CTD | X-ray | 1.6 Å | A/C=572-583 |
| 8YV3 | X-ray | 1.68 Å | A/D=1080-1109 |
| 1Q7D | X-ray | 1.8 Å | A/B/C=133-153 |
| 5CTI | X-ray | 1.9 Å | A/C=572-583 |
| 3EJH | X-ray | 2.1 Å | E/F=956-977 |
| 5CVA | X-ray | 2.1 Å | B/C/E/F=554-583, B/E=593-629 |
| 5K31 | X-ray | 2.2 Å | A/B/C/D/E/F=1219-1464 |
| 5CVB | X-ray | 2.25 Å | A/D=572-583, B/C/E/F=554-583, B/E=593-606 |
| 5OU8 | X-ray | 2.5 Å | C/D/E=1178-1192 |
| 5OU9 | X-ray | 2.5 Å | C/D/E=1172-1192 |
| 3GXE | X-ray | 2.6 Å | E/F=254-275 |
| 7E7B | EM | 2.6 Å | A/B/C=1156-1462 |
| 7E7D | EM | 3.2 Å | A/B/C=1156-1462 |
| 2LLP | NMR | A/B/C=949-965 |
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