Alpha-fetoprotein (AFP) is a 609-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02771.
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The mean pLDDT of this model is 88.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties
Dimeric and trimeric forms have been found in addition to the monomeric form
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MRK | X-ray | 1.4 Å | P=137-145 |
| 7RE7 | X-ray | 2.55 Å | C/F=158-166 |
| 7YIM | EM | 2.6 Å | A=1-609 |
| 7RE8 | X-ray | 2.82 Å | C/F=158-166 |
| 8X1N | EM | 3.31 Å | A=1-609 |
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