Serotransferrin (TF) is a 698-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P02787.
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The mean pLDDT of this model is 93.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 85% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation
Monomer (Probable) (PubMed:22327295). Part of a complex composed of SLC40A1/ferroportin, TF/transferrin and HEPH/hephaestin that transfers iron from cells to transferrin (PubMed:37277838). Interacts with TFRC (PubMed:29950717)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1RYO | X-ray | 1.2 Å | A=20-346 |
| 1A8E | X-ray | 1.6 Å | A=22-350 |
| 3SKP | X-ray | 1.7 Å | A=358-698 |
| 1A8F | X-ray | 1.8 Å | A=22-350 |
| 1D3K | X-ray | 1.8 Å | A=22-350 |
| 1FQE | X-ray | 1.8 Å | A=20-350 |
| 3FGS | X-ray | 1.8 Å | A=20-356 |
| 1JQF | X-ray | 1.85 Å | A=20-353 |
| 1OQG | X-ray | 1.9 Å | A=20-354 |
| 1D4N | X-ray | 2.0 Å | A=22-350 |
| 1N84 | X-ray | 2.05 Å | A=20-350 |
| 1FQF | X-ray | 2.1 Å | A=20-350 |
| 1N7X | X-ray | 2.1 Å | A=20-350 |
| 3V83 | X-ray | 2.1 Å | A/B/C/D/E/F=1-698 |
| 1BP5 | X-ray | 2.2 Å | A/B/C/D=20-356 |
| 1N7W | X-ray | 2.2 Å | A=22-350 |
| 28MR | X-ray | 2.26 Å | A=20-698 |
| 28MS | X-ray | 2.37 Å | A=20-698 |
| 1DTG | X-ray | 2.4 Å | A=20-353 |
| 1OQH | X-ray | 2.4 Å | A=20-354 |
Showing 20 of 60 experimental structures (best resolution first).
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