Protein E7 (E7) is a 98-residue protein from Human papillomavirus type 16. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P03129.
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The mean pLDDT of this model is 81.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction…
Homodimer (PubMed:11123931). Homooligomer (PubMed:15035602). Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity (PubMed:1316611). Interacts with host EP300; this interaction represses EP300 transcriptional activity (PubMed:12970734). Forms a complex with CHD4 and HDAC1, thereby altering the action of host histone deacetylation. A…
Host cytoplasm, Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6APN | X-ray | 2.22 Å | A/B=82-90 |
| 4YOZ | X-ray | 2.25 Å | B=21-29 |
| 7SR3 | X-ray | 2.49 Å | A/C=11-22 |
| 7SQP | X-ray | 2.53 Å | A/C=11-22 |
| 7SR0 | X-ray | 2.54 Å | A/C=11-19 |
| 7SR4 | X-ray | 2.59 Å | A/C=11-24 |
| 7SSH | X-ray | 2.73 Å | A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e=11-24 |
| 7ST3 | X-ray | 2.78 Å | A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c/e=11-24 |
| 9UUK | X-ray | 3.2 Å | B=22-32 |
| 9UUL | X-ray | 3.3 Å | B=22-39 |
| 9UUJ | X-ray | 3.7 Å | B=22-39 |
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