Apoptosis regulator BHRF1 (BHRF1) is a 191-residue protein from Epstein-Barr virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P03182.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell. In addition, plays a role in the inhibiton of host BECN1-mediated starvation-induced autophagy without affecting basal levels of autophagy (PubMed:37776275)
Interacts with isoform 1 of host VRK2; this interaction is involved in protecting cells from apoptosis (PubMed:16963744). Interacts with host PRA1; this interaction seems to modulate BHRF1 anti-apoptotic activity (PubMed:11373297). Interacts with host BCL2L11 (PubMed:18084238, PubMed:19293378, PubMed:21203485). Interacts with host BAD and BBC3 (PubMed:21203485). Interacts with BALF1; BALF1…
Host membrane, Host mitochondrion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7P9W | X-ray | 2.0 Å | A=1-160 |
| 2XPX | X-ray | 2.05 Å | A=1-160 |
| 8SM5 | X-ray | 2.61 Å | A/C/E/G/I=2-157 |
| 7P33 | X-ray | 2.79 Å | A/B/C/D/E=1-160 |
| 1Q59 | NMR | A=1-160 |
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