Lytic switch protein BZLF1 (BZLF1) is a 245-residue protein from Epstein-Barr virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P03206.
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The mean pLDDT of this model is 53.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 8% |
| 70 to 90 | Confident: backbone generally right | 21% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 58% |
What pLDDT means and how to read it
Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (Probable) (PubMed:8404860). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome (PubMed:15361873, PubMed:34893887). Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes (PubMed:30926617). Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (Probable) (PubMed:22022468, PubMed:34893887). Activates preferentially the…
Homodimer (PubMed:11333921, PubMed:15078966, PubMed:28158710). Interacts (via b-ZIP domain) with the DNA polymerase processivity factor BMRF1 (via N-terminus); this interaction may inhibit BZLF1-induced transcription of the BMRF1 promoter (PubMed:8764021). Interacts with human UBN1, CRTC2 and RACK1 (PubMed:10725330, PubMed:10849009, PubMed:19164291). Interacts (via N-terminus) with human PAX5…
Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3SPV | X-ray | 1.3 Å | C=190-197 |
| 3VFN | X-ray | 1.5 Å | C=52-64 |
| 1ZSD | X-ray | 1.7 Å | C=54-64 |
| 3VFO | X-ray | 1.7 Å | C=52-64 |
| 2AXF | X-ray | 1.8 Å | C=77-86 |
| 3VFP | X-ray | 1.85 Å | C=52-64 |
| 3VFR | X-ray | 1.85 Å | C=52-64 |
| 2AXG | X-ray | 2.0 Å | C=77-86 |
| 3KWW | X-ray | 2.18 Å | C=52-64 |
| 2C9L | X-ray | 2.25 Å | Y/Z=175-236 |
| 5SZX | X-ray | 2.25 Å | A/B=175-236 |
| 2AK4 | X-ray | 2.5 Å | C/H/M/S=52-64 |
| 7NX5 | X-ray | 2.5 Å | A/B/E/F=175-236 |
| 2NX5 | X-ray | 2.7 Å | C/H/M/S=54-64 |
| 3KXF | X-ray | 3.1 Å | Q/R/S/T=52-64 |
| 2C9N | X-ray | 3.3 Å | Y/Z=175-236 |
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