Early E1A protein is a 289-residue protein from Human adenovirus C serotype 5. This is its AlphaFold structure prediction, created 3 Sept 2026. UniProt accession: P03255.
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The mean pLDDT of this model is 60.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 34% |
| Below 50 | Very low: often disordered regions | 33% |
What pLDDT means and how to read it
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E1A protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes and of the E2 region of the adenoviral genome. Release of E2F1 leads to the ARF-mediated inhibition of MDM2 and causes TP53/p53 to accumulate because it is not targeted for…
Interacts with host UBE2I; this interaction interferes with polySUMOylation (Probable) (PubMed:20543865, PubMed:8824223). Interacts with host RB1; this interaction induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting the activity of RB1 and activating E2F1-regulated genes (PubMed:17974914). Interacts with host ATF7; the interaction enhances ATF7-mediated viral transactivation…
Host nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2R7G | X-ray | 1.67 Å | B/D/E=40-49 |
| 6H6D | X-ray | 2.4 Å | C/F=234-243 |
| 6H6H | X-ray | 2.4 Å | C/F=234-243 |
| 2KJE | NMR | B=53-91 |
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