RNA-directed RNA polymerase catalytic subunit (PB1) is a 757-residue protein from Influenza A virus. This is its AlphaFold structure prediction, created 3 Sept 2026. UniProt accession: P03431.
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The mean pLDDT of this model is 83.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 52% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus) (PubMed:18660801, PubMed:19461581, PubMed:28169297). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation (PubMed:19461581, PubMed:28169297). Interacts (via C-terminus) with human PKP2 (via N-terminus); the…
Host nucleus, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3A1G | X-ray | 1.7 Å | A/C=678-757 |
| 2ZTT | X-ray | 2.1 Å | A/C=679-757 |
| 2ZNL | X-ray | 2.3 Å | B=1-81 |
| 9IM6 | EM | 3.21 Å | B=182-217 |
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