Vitronectin (VTN) is a 478-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04004.
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The mean pLDDT of this model is 67.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 30% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 32% |
What pLDDT means and how to read it
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway
Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1, insulin and C1QBP
Secreted, extracellular space, Parasitophorous vacuole
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RJ9 | X-ray | 1.7 Å | A/B=154-474 |
| 6O5E | X-ray | 1.9 Å | A/B=154-474 |
| 1OC0 | X-ray | 2.28 Å | B=20-70 |
| 3BT2 | X-ray | 2.5 Å | B=21-60 |
| 3BT1 | X-ray | 2.8 Å | B=21-60 |
| 4K24 | X-ray | 4.5 Å | B=21-60 |
| 1S4G | NMR | A=20-70 | |
| 1SSU | NMR | A=20-70 | |
| 2JQ8 | NMR | A=20-66 |
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