Vitamin K-dependent protein C (PROC) is a 461-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04070.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 82.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265, PubMed:39880037). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845)
Synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin. Interacts (activated) with iripin-8, a serine…
Secreted, Golgi apparatus, Endoplasmic reticulum
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1LQV | X-ray | 1.6 Å | C/D=43-75 |
| 3JTC | X-ray | 1.6 Å | C/D=43-75 |
| 4DT7 | X-ray | 1.9 Å | E/F=204-223 |
| 6M3B | X-ray | 2.2 Å | A=212-461, D=43-197 |
| 1AUT | X-ray | 2.8 Å | C=212-461, L=84-197 |
| 3F6U | X-ray | 2.8 Å | H=212-451, L=91-188 |
| 9MOV | EM | 3.0 Å | C=43-188, D=212-451 |
| 9MOT | EM | 3.15 Å | D=212-451 |
| 8JRV | EM | 3.3 Å | R=205-216 |
| 9BVM | EM | 3.4 Å | P=19-88 |
| 8JRU | EM | 3.5 Å | R=205-216 |
| 6M3C | X-ray | 3.7 Å | A/C/G=212-461, B/D/I=43-197 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.