Histone H2A type 1-B/E (H2AC4) is a 130-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04908.
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The mean pLDDT of this model is 90.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7VZ4 | EM | 1.89 Å | C/G=2-130 |
| 6ACL | X-ray | 1.92 Å | B=93-102 |
| 8I17 | X-ray | 1.98 Å | A/D/G=14-113 |
| 5B0Z | X-ray | 1.99 Å | C/G=1-130 |
| 5Y0D | X-ray | 1.99 Å | C/G=1-130 |
| 6IPU | X-ray | 1.99 Å | C/G=14-120 |
| 8UQA | X-ray | 2.05 Å | K=13-106 |
| 5Y0C | X-ray | 2.09 Å | C/G=1-130 |
| 8Q3E | X-ray | 2.17 Å | CCC/GGG=14-120 |
| 5X7X | X-ray | 2.18 Å | C/G=1-130 |
| 5AV6 | X-ray | 2.2 Å | C/G=1-130 |
| 5AV8 | X-ray | 2.2 Å | C/G=1-130 |
| 5AV9 | X-ray | 2.2 Å | C/G=1-130 |
| 5B31 | X-ray | 2.2 Å | C=1-130 |
| 6KE9 | X-ray | 2.22 Å | C/G=15-119 |
| 6IQ4 | X-ray | 2.25 Å | C/G=15-120 |
| 6JXD | X-ray | 2.25 Å | C/G=14-119 |
| 8KB5 | EM | 2.26 Å | C/G=1-130 |
| 8Q3X | X-ray | 2.3 Å | CCC/GGG=14-120 |
| 8UQ9 | X-ray | 2.3 Å | A/a=13-106 |
Showing 20 of 349 experimental structures (best resolution first).
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