Histone H2A.2 (HTA2) is a 132-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P04912.
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The mean pLDDT of this model is 89.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 78% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers (PubMed:15610740). The octamer wraps approximately 147 bp of DNA (PubMed:15610740). Interacts with NAP1; the interaction is direct and for the nuclear import of histone H2A-H2B dimers and their assembly into nucleosomes (PubMed:18086883,…
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9B3I | EM | 2.88 Å | B=2-132 |
| 4JJN | X-ray | 3.09 Å | C/G=2-132 |
| 4KUD | X-ray | 3.2 Å | C/G=1-132 |
| 9B31 | EM | 3.2 Å | B=2-132 |
| 8F0X | EM | 3.21 Å | B=2-132 |
| 8F1E | EM | 3.28 Å | B=2-132 |
| 7E9C | EM | 3.5 Å | C/G=1-132 |
| 9B3F | EM | 3.54 Å | B=2-132 |
| 8QKU | EM | 3.8 Å | E/F=1-127 |
| 7E9F | EM | 4.0 Å | C/G=1-132 |
| 8QKV | EM | 4.7 Å | E/F=1-127 |
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