Integrin beta-3 (ITGB3) is a 788-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05106.
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The mean pLDDT of this model is 87.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 29% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor (VWF). Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of…
Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2. Interacts with EMP2;…
Cell membrane, Cell projection, lamellipodium membrane, Cell junction, focal adhesion, Postsynaptic cell membrane, Synapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1MIZ | X-ray | 1.9 Å | A=765-769 |
| 7UDH | X-ray | 2.0 Å | B/D=27-498 |
| 7UBR | X-ray | 2.05 Å | B/D=27-498 |
| 6BXJ | X-ray | 2.09 Å | A=27-135, A=378-714 |
| 1MK7 | X-ray | 2.2 Å | A/C=765-775 |
| 3T3P | X-ray | 2.2 Å | B/D=27-498 |
| 7TMZ | X-ray | 2.2 Å | B/D=27-497 |
| 2Q6W | X-ray | 2.25 Å | C/F=50-61 |
| 3NIG | X-ray | 2.25 Å | B/D=27-497 |
| 7U9V | X-ray | 2.25 Å | B/D=27-497 |
| 3NID | X-ray | 2.3 Å | B/D=27-497 |
| 3ZE2 | X-ray | 2.35 Å | B/D=27-498 |
| 7L8P | X-ray | 2.35 Å | B/D=27-498 |
| 7UCY | X-ray | 2.35 Å | B/D=27-498 |
| 7UKT | X-ray | 2.37 Å | B/D=27-498 |
| 6BXB | X-ray | 2.39 Å | A/B=27-135, A/B=378-548 |
| 2VDR | X-ray | 2.4 Å | B=27-487 |
| 3NIF | X-ray | 2.4 Å | B/D=27-497 |
| 7UJK | X-ray | 2.43 Å | B/D=27-498 |
| 3ZDX | X-ray | 2.45 Å | B/D=27-498 |
Showing 20 of 121 experimental structures (best resolution first).
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