Intercellular adhesion molecule 1 (ICAM1) is a 532-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P05362.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 88.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength (PubMed:3086451, PubMed:3340213, PubMed:38195629). Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (PubMed:17875742).…
Homodimer (PubMed:12526797, PubMed:15099525). Interacts with MUC1 and promotes cell aggregation in epithelial cells (PubMed:11173916). Interacts with ARHGEF26/SGEF (PubMed:17875742). Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells (PubMed:23858057)
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1IAM | X-ray | 2.1 Å | A=28-212 |
| 7BG7 | EM | 2.4 Å | B=28-480 |
| 2OZ4 | X-ray | 2.7 Å | A=213-477 |
| 5MZA | X-ray | 2.78 Å | B=28-212 |
| 1IC1 | X-ray | 3.0 Å | A/B=28-217 |
| 1P53 | X-ray | 3.06 Å | A/B=212-477 |
| 1D3L | X-ray | 3.25 Å | A=28-212 |
| 1MQ8 | X-ray | 3.3 Å | A/C=28-318 |
| 3TCX | X-ray | 3.6 Å | A/C/E/G/I/K/M/O/Q/S/U/W/Y/a=29-112 |
| 6S8U | X-ray | 3.67 Å | B=28-212 |
| 6EIT | EM | 3.9 Å | 4=28-112 |
| 1Z7Z | EM | 8.0 Å | I=28-477 |
| 1D3I | EM | 26.0 Å | I=28-212 |
| 1D3E | EM | 28.0 Å | I=28-212 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.