Cholecystokinin (CCK) is a 115-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06307.
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The mean pLDDT of this model is 65.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 5% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 57% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7MBX | EM | 1.95 Å | P=96-103 |
| 7MBY | EM | 2.44 Å | P=96-103 |
| 9BKK | EM | 2.51 Å | P=96-103 |
| 9BKJ | EM | 2.59 Å | P=96-103 |
| 7EZM | EM | 2.9 Å | P=96-103 |
| 7EZK | EM | 3.1 Å | P=96-103 |
| 8IA7 | EM | 3.1 Å | L=96-103 |
| 7EZH | EM | 3.2 Å | P=96-103 |
| 7XOU | EM | 3.2 Å | L=96-103 |
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