Cyclin-dependent kinase 1 (CDK1) is a 297-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P06493.
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The mean pLDDT of this model is 89.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 69% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:16933150, PubMed:17459720, PubMed:18356527, PubMed:19509060, PubMed:19917720, PubMed:20171170, PubMed:20935635, PubMed:20937773, PubMed:21063390, PubMed:2188730, PubMed:23355470, PubMed:2344612, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:27814491, PubMed:30139873, PubMed:30704899, PubMed:40440427). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, ASB7, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA,…
Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin (PubMed:20360007). The cyclin subunit imparts substrate specificity to the complex (PubMed:20360007). Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex known as maturation promoting factor (MPF) (PubMed:20360007, PubMed:2188730, PubMed:2344612). Promotes G2-M…
Nucleus, Cytoplasm, Mitochondrion, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6GU2 | X-ray | 2.0 Å | A=1-297 |
| 5LQF | X-ray | 2.06 Å | A/D=1-297 |
| 6TWN | X-ray | 2.28 Å | C/D=207-223 |
| 4Y72 | X-ray | 2.3 Å | A=1-297 |
| 5HQ0 | X-ray | 2.3 Å | A=1-297 |
| 6GU6 | X-ray | 2.33 Å | A=1-297 |
| 4YC6 | X-ray | 2.6 Å | A/C/E/G=1-297 |
| 6GU3 | X-ray | 2.65 Å | A=1-297 |
| 4YC3 | X-ray | 2.7 Å | A=1-297 |
| 6GU4 | X-ray | 2.73 Å | A=1-297 |
| 6GU7 | X-ray | 2.75 Å | A/C/E/G=1-297 |
| 9SKQ | EM | 3.4 Å | A=1-297 |
| 7NJ0 | EM | 3.6 Å | B=1-297 |
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