Gastrin-releasing peptide (GRP) is a 148-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07492.
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The mean pLDDT of this model is 63.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 7% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 60% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of…
Secreted, Cytoplasmic vesicle, secretory vesicle lumen, Cell projection, neuron projection
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7W3Z | EM | 3.0 Å | L=39-50 |
| 8H0Q | EM | 3.3 Å | L=42-50 |
| 2N0B | NMR | A=41-50 | |
| 2N0C | NMR | A=41-50 | |
| 2N0D | NMR | A=41-50 | |
| 2N0E | NMR | A=41-50 | |
| 2N0F | NMR | A=41-50 | |
| 2N0G | NMR | A=41-50 | |
| 2N0H | NMR | A=41-50 |
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