Beta-1 adrenergic receptor (ADRB1) is a 483-residue protein from Meleagris gallopavo. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07700.
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The mean pLDDT of this model is 73.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 27% |
What pLDDT means and how to read it
G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity (PubMed:18594507). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac function. Involved in the regulation of sleep/wake behaviors (By similarity)
Interacts (via PDZ-binding motif) with RAPGEF2 (via PDZ domain); the interaction is direct and is required for Ras activation upon ligand stimulation. Interacts (via PDZ-binding motif) with GOPC, MAGI3 and DLG4; interaction mediates ADRB1 trafficking and signaling in a cell-specific manner
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4BVN | X-ray | 2.1 Å | A=33-368 |
| 4AMJ | X-ray | 2.3 Å | A/B=33-368 |
| 5A8E | X-ray | 2.4 Å | A=33-368 |
| 2Y00 | X-ray | 2.5 Å | A/B=33-368 |
| 6H7N | X-ray | 2.5 Å | A/B=44-368 |
| 8DCS | EM | 2.5 Å | R=33-367 |
| 2Y01 | X-ray | 2.6 Å | A/B=33-368 |
| 2Y02 | X-ray | 2.6 Å | A/B=33-368 |
| 7JJO | EM | 2.6 Å | R=31-367 |
| 8DCR | EM | 2.6 Å | R=33-367 |
| 2VT4 | X-ray | 2.7 Å | A/B/C/D=31-368 |
| 3ZPR | X-ray | 2.7 Å | A/B=33-368 |
| 6H7L | X-ray | 2.7 Å | A/B=44-368 |
| 6IBL | X-ray | 2.7 Å | A/B=44-368 |
| 6H7M | X-ray | 2.76 Å | A/B=44-368 |
| 3ZPQ | X-ray | 2.8 Å | A/B=33-368 |
| 6H7J | X-ray | 2.8 Å | A/B=44-368 |
| 6H7O | X-ray | 2.8 Å | A/B=44-368 |
| 2Y03 | X-ray | 2.85 Å | A/B=33-368 |
| 7S0F | EM | 2.96 Å | R=31-367 |
Showing 20 of 31 experimental structures (best resolution first).
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