Profilin-1 (PFN1) is a 140-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P07737.
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The mean pLDDT of this model is 95.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 94% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR
Found in a complex with XPO6, Ran, ACTB and PFN1 (PubMed:14592989). Interacts with ACTB (PubMed:10411937). Interacts with VASP (PubMed:17914456, PubMed:18689676). Interacts with HTT (PubMed:18573880). Interacts with SH3BGRL (PubMed:34331014). Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio (PubMed:17914456, PubMed:18689676). Interacts with ACTMAP (PubMed:36173861)
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2PBD | X-ray | 1.5 Å | P=2-140 |
| 8BJH | X-ray | 1.69 Å | B=2-140 |
| 8BJJ | X-ray | 1.7 Å | C=2-140 |
| 8BJI | X-ray | 1.75 Å | B=2-140 |
| 2PAV | X-ray | 1.8 Å | P=2-140 |
| 1FIL | X-ray | 2.0 Å | A=2-140 |
| 6NBE | X-ray | 2.0 Å | P=1-140 |
| 4X1L | X-ray | 2.16 Å | A=1-140 |
| 4X1M | X-ray | 2.17 Å | A=1-140 |
| 1AWI | X-ray | 2.2 Å | A/B=3-140 |
| 1CF0 | X-ray | 2.2 Å | A/B=3-140 |
| 8BR0 | X-ray | 2.22 Å | B/D=2-140 |
| 4X25 | X-ray | 2.23 Å | A/B=1-140 |
| 1CJF | X-ray | 2.3 Å | A/B=2-140 |
| 1FIK | X-ray | 2.3 Å | A=2-140 |
| 3CHW | X-ray | 2.3 Å | P=2-140 |
| 6NBW | X-ray | 2.5 Å | P=1-140 |
| 6NAS | X-ray | 2.9 Å | P=1-140 |
| 9AZP | EM | 3.79 Å | J=2-140 |
| 7P1H | EM | 3.9 Å | P=1-140 |
Showing 20 of 22 experimental structures (best resolution first).
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