M protein, serotype 6 (emm6) is a 483-residue protein from Streptococcus pyogenes. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08089.
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The mean pLDDT of this model is 74.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Mediates the attachment of S.pyogenes to skin epithelial cells through the binding of the human membrane cofactor protein CD46. Also binds to the factor H and factor H-like protein 1. These interactions could contribute to the fact that the M6 protein protects the bacterium from the phagocytosis by regulating the complement activation on the bacterial surface
Secreted, cell wall
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9MMX | X-ray | 1.9 Å | C/D/E/F=74-157 |
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