9MMX: M6 protein with Factor H 6-7 domain
M6 protein with Factor H 6-7 domain. Determined by X-ray diffraction at 1.9 Å resolution. Released 4 Feb 2026.
- Method
- X-ray diffraction
- Resolution
- 1.9 Å
- Organisms
- Homo sapiens, Streptococcus pyogenes JRS4
- Chains
- 6
- Atoms
- 4,185
- Mol. weight
- 68.96 kDa
- Released
- 4 Feb 2026
Explore 9MMX in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9MMX contains 14 α-helices and 28 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 5 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 325 | 1 | 1 |
| β-strand | 333-335 | 3 | 2 |
| α-helix | 338-341 | 4 | |
| α-helix | 342-344 | 3 | |
| β-strand | 347 | 1 | 1 |
| β-strand | 352-357 | 6 | 2 |
| β-strand | 361-362 | 2 | 3 |
| β-strand | 369-375 | 7 | 2 |
| β-strand | 378-380 | 3 | 2 |
| β-strand | 386-387 | 2 | 3 |
| β-strand | 388-390 | 3 | 4 |
| α-helix | 391-393 | 3 | |
| β-strand | 397 | 1 | 5 |
| β-strand | 405-407 | 3 | 4 |
| β-strand | 411-413 | 3 | 6 |
| β-strand | 416 | 1 | 5 |
| α-helix | 417 | 1 | |
| α-helix | 423-425 | 3 | |
| β-strand | 428-432 | 5 | 6 |
| β-strand | 435-437 | 3 | 6 |
Chain B: 5 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 326-328 | 3 | |
| β-strand | 333-335 | 3 | 7 |
| α-helix | 338-341 | 4 | |
| α-helix | 342-344 | 3 | |
| β-strand | 352-357 | 6 | 7 |
| β-strand | 361-362 | 2 | 8 |
| β-strand | 369-374 | 6 | 7 |
| β-strand | 379-380 | 2 | 7 |
| β-strand | 386-387 | 2 | 8 |
| β-strand | 388-390 | 3 | 9 |
| α-helix | 391-393 | 3 | |
| β-strand | 397 | 1 | 10 |
| β-strand | 405-407 | 3 | 9 |
| β-strand | 411-413 | 3 | 11 |
| β-strand | 416 | 1 | 10 |
| α-helix | 417 | 1 | |
| β-strand | 428-432 | 5 | 11 |
| β-strand | 435-437 | 3 | 11 |
Chain C: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 79-150 | 72 | |
Chain D: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 80-153 | 74 | |
Chain E: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 73-148 | 76 | |
Chain F: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 74-154 | 81 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Complement factor H | A, B | protein | 125 | Homo sapiens | P08603 (AlphaFold model) |
| M protein, serotype 6 | C, D, E, F | protein | 88 | Streptococcus pyogenes JRS4 | P08089 (AlphaFold model) |
Sequence of entity 1 (A, B), FASTA
>9MMX_1 Complement factor H (chains A, B)
MGTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDG
WSPAVPCLRKCYFPYLENGYNQNYGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSP
TPRCI
Sequence of entity 2 (C, D, E, F), FASTA
>9MMX_2 M protein, serotype 6 (chains C, D, E, F)
GPGSNDKLTTENNNLTDQNKNLTTENKNLTDQNKNLTTENKNLTDQNKNLTTENKELKAE
ENRLTTENKGLTKKLSEAEEEAANKERE
Primary citation
Structural mechanisms for the recruitment of factor H by Streptococcus pyogenes. Kumar, A., Wang, K.C., Ghosh, P. Structure (2026) 34:778. DOI 10.1016/j.str.2026.02.010 · PubMed
Other PDB entries of the same protein (UniProt P08603 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 4K12 1.08 Å, Structural Basis for Host Specificity of Factor H Binding by Streptococcus pneumoniae
- 3R62 1.52 Å, Structure of complement regulator Factor H mutant, T1184R.
- 3KZJ 1.65 Å, Structure of complement Factor H variant R1203A
- 2G7I 1.75 Å, Structure of Human Complement Factor H Carboxyl Terminal Domains 19-20: a Basis for…
- 3SW0 1.8 Å, Structure of the C-terminal region (modules 18-20) of complement regulator Factor H
- 6ATG 1.8 Å, Insights to complement factor H recruitment by the borrelial CspZ protein as revealed by…
- 9MLU 1.82 Å, FbaA with Factor H 6-7 domain
- 3KXV 2.0 Å, Structure of complement Factor H variant Q1139A
- 3OXU 2.1 Å, Complement components factor H CCP19-20 and C3d in complex
- 4ONT 2.15 Å, Ternary host recognition complex of complement factor H, C3d, and sialic acid
- 6ZH1 2.2 Å, Crystal structure of complex between FH19-20 and FhbA protein from Borrelia hermsii
- 4ZH1 2.24 Å, Complement factor H in complex with the GM1 glycan
Browse structure collections
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