Muscarinic acetylcholine receptor M4 (CHRM4) is a 479-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08173.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 75.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase
Cell membrane, Postsynaptic cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7TRP | EM | 2.4 Å | R=1-479 |
| 8FX5 | EM | 2.45 Å | R=1-479 |
| 7TRQ | EM | 2.5 Å | R=1-479 |
| 9N09 | EM | 2.57 Å | R=2-479 |
| 5DSG | X-ray | 2.6 Å | A/B=22-238, A/B=390-478 |
| 8E9X | EM | 2.7 Å | A=1-479 |
| 9KVP | EM | 2.79 Å | C=2-23 |
| 7TRK | EM | 2.8 Å | R=1-479 |
| 7TRS | EM | 2.8 Å | R=1-479 |
| 9KV6 | EM | 2.88 Å | E=2-23 |
| 6KP6 | X-ray | 3.0 Å | A=22-227, A=390-479 |
| 9KUG | EM | 3.07 Å | A=2-23 |
| 9KX6 | EM | 3.11 Å | A=2-23 |
| 9KWX | EM | 3.13 Å | A=2-23 |
| 9KWG | EM | 3.15 Å | A=2-23 |
| 9UMR | EM | 3.15 Å | D=2-23 |
| 9KV8 | EM | 3.17 Å | C=2-23 |
| 7LD3 | EM | 3.2 Å | R=2-23 |
| 9UMX | EM | 3.2 Å | A=2-23 |
| 9KUT | EM | 3.29 Å | C=2-23 |
Showing 20 of 37 experimental structures (best resolution first).
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.