Polyprotein P1234 is a 102-residue protein from Semliki forest virus. This is its AlphaFold structure prediction, created 3 Jul 2025. UniProt accession: P08411.
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The mean pLDDT of this model is 65.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 73% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Inactive precursor of the viral replicase, which is activated by cleavages carried out by the viral protease nsP2
Interacts with non-structural protein 3 (By similarity). Interacts with RNA-directed RNA polymerase nsP4 (By similarity). Interacts with protease nsP2 (By similarity). interacts with itself (By similarity)
Host cytoplasmic vesicle membrane, Host cell membrane, Host cell projection, host filopodium, Host nucleus, Host cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5FW5 | X-ray | 1.92 Å | C=1785-1809 |
| 5DRV | X-ray | 2.75 Å | B=1785-1792 |
| 1FW5 | NMR | A=245-264 |
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