Integrin alpha-IIb (ITGA2B) is a 1039-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08514.
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The mean pLDDT of this model is 88.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between…
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7SC4 | X-ray | 1.85 Å | A/B=1019-1039 |
| 7UDH | X-ray | 2.0 Å | A/C=32-488 |
| 7UBR | X-ray | 2.05 Å | A/C=32-485 |
| 3T3P | X-ray | 2.2 Å | A/C=32-488 |
| 7TMZ | X-ray | 2.2 Å | A/C=32-485 |
| 3NIG | X-ray | 2.25 Å | A/C=32-488 |
| 7U9V | X-ray | 2.25 Å | A/C=32-485 |
| 3NID | X-ray | 2.3 Å | A/C=32-488 |
| 3ZE2 | X-ray | 2.35 Å | A/C=32-488 |
| 7L8P | X-ray | 2.35 Å | A/C=32-488 |
| 7UCY | X-ray | 2.35 Å | A/C=32-488 |
| 7UKT | X-ray | 2.37 Å | A/C=32-488 |
| 2VDR | X-ray | 2.4 Å | A=32-483 |
| 3NIF | X-ray | 2.4 Å | A/C=32-488 |
| 7UJK | X-ray | 2.43 Å | A/C=32-488 |
| 3ZDX | X-ray | 2.45 Å | A/C=32-488 |
| 3ZDY | X-ray | 2.45 Å | A/C=32-488 |
| 7TCT | X-ray | 2.5 Å | A/C=32-488 |
| 7UJE | X-ray | 2.5 Å | A/C=32-485 |
| 2VDO | X-ray | 2.51 Å | A=32-483 |
Showing 20 of 78 experimental structures (best resolution first).
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