Myosin-2 heavy chain (mhcA) is a 2116-residue protein from Dictyostelium discoideum. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08799.
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The mean pLDDT of this model is 71.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 9% |
| 70 to 90 | Confident: backbone generally right | 45% |
| 50 to 70 | Low: treat with caution | 42% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin
Myosin-2 heavy chain is two-headed. It self-assembles into filaments. Hexamer of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Associates with elmoA
Cytoplasm, cell cortex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1W9I | X-ray | 1.75 Å | A=1-759 |
| 3MYK | X-ray | 1.84 Å | X=2-759 |
| 6Z7T | X-ray | 1.88 Å | A/B=2-761 |
| 1LVK | X-ray | 1.9 Å | A=1-759 |
| 1VOM | X-ray | 1.9 Å | A=1-759 |
| 2AKA | X-ray | 1.9 Å | A=2-765 |
| 1W9L | X-ray | 1.95 Å | A=1-761 |
| 1D0X | X-ray | 2.0 Å | A=1-761 |
| 1D0Y | X-ray | 2.0 Å | A=1-761 |
| 1D0Z | X-ray | 2.0 Å | A=1-761 |
| 1D1A | X-ray | 2.0 Å | A=1-761 |
| 1D1B | X-ray | 2.0 Å | A=1-761 |
| 1MMD | X-ray | 2.0 Å | A=1-759 |
| 1W9J | X-ray | 2.0 Å | A=1-761 |
| 1YV3 | X-ray | 2.0 Å | A=2-759 |
| 3BZ7 | X-ray | 2.0 Å | A=2-759 |
| 3MYL | X-ray | 2.0 Å | X=2-759 |
| 3MYH | X-ray | 2.01 Å | X=2-759 |
| 1W9K | X-ray | 2.05 Å | A=1-761 |
| 1FMV | X-ray | 2.1 Å | A=1-759 |
Showing 20 of 49 experimental structures (best resolution first).
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