T-cell surface antigen CD2 (Cd2) is a 344-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P08921.
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The mean pLDDT of this model is 77.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function
Interacts with CD48 (PubMed:16803907). Interacts with CD58 (LFA-3) (By similarity). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (By similarity). Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1CCZ | X-ray | 1.8 Å | A=122-198 |
| 1A64 | X-ray | 2.0 Å | A/B=23-121 |
| 1CDC | X-ray | 2.0 Å | A/B=23-121 |
| 1A6P | X-ray | 2.08 Å | A/B=26-121 |
| 2DRU | X-ray | 2.6 Å | A=121-197 |
| 1HNG | X-ray | 2.8 Å | A/B=23-198 |
| 1A7B | X-ray | 3.1 Å | A/B/C/D=23-121 |
| 1T6W | NMR | A=23-121 |
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