Aerolysin (aerA) is a 493-residue protein from Aeromonas hydrophila. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P09167.
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The mean pLDDT of this model is 88.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 72% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and host cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter
Homodimer in solution; homoheptamer in the host membrane. After binding to GPI-anchored proteins in target membranes and proteolytic removal of the C-terminal propeptide, the protein assembles into a heptameric pre-pore complex. A further conformation change leads to insertion into the host membrane
Secreted, Host cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3G4N | X-ray | 2.1 Å | A/B=24-493 |
| 9FNQ | EM | 2.1 Å | A/B/C/D/E/F/G=24-447 |
| 3C0N | X-ray | 2.2 Å | A/B=24-493 |
| 9FM6 | EM | 2.2 Å | A/B/C/D/E/F/G=24-447 |
| 9FML | EM | 2.2 Å | A/B/C/D/E/F/G=24-493 |
| 9FMX | EM | 2.2 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N=24-493 |
| 9FNP | EM | 2.2 Å | A/B/C/D/E/F/G=24-447 |
| 3G4O | X-ray | 2.3 Å | A/B=24-493 |
| 9GXJ | EM | 2.3 Å | A/B/C/D/E/F/G=24-447 |
| 9IGN | EM | 2.3 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N=24-447 |
| 1Z52 | X-ray | 2.38 Å | A/B=24-493 |
| 3C0O | X-ray | 2.5 Å | A/B=24-493 |
| 1PRE | X-ray | 2.8 Å | A/B=24-493 |
| 3C0M | X-ray | 2.88 Å | A/B=24-493 |
| 5JZH | EM | 3.9 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N=24-447 |
| 5JZW | EM | 4.46 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N=24-447 |
| 5JZT | EM | 7.4 Å | A/B/C/D/E/F/G=24-447 |
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