Tropomyosin alpha-1 chain (TPM1) is a 284-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P09493.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 91.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments
Homodimer (PubMed:23170982). Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with HRG (via the HRR domain); the interaction contributes to the antiangiogenic properties of the histidine/proline-rich region (HRR) of HRG (By similarity). Interacts (via N-terminus) with LMOD2 (via N-terminus) and TMOD1 (via N-terminus) (PubMed:26873245)
Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5KHT | X-ray | 1.5 Å | A/B/C/D=1-28 |
| 3MUD | X-ray | 2.2 Å | C/D=1-29 |
| 9ZBL | EM | 2.79 Å | M/N/O/P=1-284 |
| 9ZBP | EM | 3.12 Å | M/N/O/P=1-284 |
| 8ZB7 | EM | 3.19 Å | L/N/O/P=45-210 |
| 8EFH | EM | 3.3 Å | O/P=1-284 |
| 8EFI | EM | 3.4 Å | O/P=1-284 |
| 8ENC | EM | 3.6 Å | O/P=1-284 |
| 6X5Z | EM | 4.24 Å | O/P=1-284 |
| 6KN8 | EM | 4.8 Å | P/Q/W/X=11-284, R/S/Y/Z=1-29 |
| 7UTI | EM | 4.8 Å | W/b/e/f/g/h/i/j=1-284 |
| 6KN7 | EM | 6.6 Å | P/Q/W/X=11-284, R/S/Y/Z=1-29 |
| 7UTL | EM | 6.6 Å | W/Z/a/b/g/h/i/j=1-284 |
| 6UT2 | NMR | B/C=1-14 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.