Enterotoxin type C-3 (entC3) is a 266-residue protein from Staphylococcus aureus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0A0L5.
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The mean pLDDT of this model is 91.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed:10229190, PubMed:28849041). Also causes the intoxication staphylococcal food poisoning syndrome (By similarity)
Interacts with MHC class II molecules composed of alpha/HLA-DRA and beta/HLA-DRB1 chains (PubMed:10229190). Interacts with host T-cell receptor/TCR beta variable chain TRBV8-2 (PubMed:10229190, PubMed:20836565)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2AQ2 | X-ray | 1.8 Å | B=28-266 |
| 1KLU | X-ray | 1.93 Å | D=28-266 |
| 3BVG | X-ray | 2.0 Å | A=28-266 |
| 3BVM | X-ray | 2.0 Å | A=28-266 |
| 2AQ1 | X-ray | 2.1 Å | B/D/F/H=28-266 |
| 3BYY | X-ray | 2.2 Å | B=28-266 |
| 1SJH | X-ray | 2.25 Å | D=28-266 |
| 1JWU | X-ray | 2.3 Å | D=28-266 |
| 2AQ3 | X-ray | 2.3 Å | B/D/F/H=28-266 |
| 2IPK | X-ray | 2.3 Å | D=28-266 |
| 3BVZ | X-ray | 2.3 Å | A=28-266 |
| 3BYT | X-ray | 2.3 Å | B/D/F/H=28-266 |
| 3BZD | X-ray | 2.3 Å | B=28-266 |
| 1KLG | X-ray | 2.4 Å | D=28-266 |
| 1SJE | X-ray | 2.45 Å | D=28-266 |
| 1T5X | X-ray | 2.5 Å | D=28-266 |
| 1JWS | X-ray | 2.6 Å | D=28-266 |
| 1JWM | X-ray | 2.7 Å | D=28-266 |
| 1JCK | X-ray | 3.5 Å | B/D=28-266 |
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