Enterotoxin type H (entH) is a 241-residue protein from Staphylococcus aureus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0A0M0.
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The mean pLDDT of this model is 91.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 88% |
| 70 to 90 | Confident: backbone generally right | 2% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules via their alpha domain, in particular TRAV27 (PubMed:12682246, PubMed:17709482, PubMed:21081917). In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of pro-inflammatory cytokines (PubMed:10586065, PubMed:12682246). Also causes the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death (PubMed:16213675)
Interacts with host MHC class II molecules composed of alpha/HLA-DRA and beta/HLA-DRB1 chains (PubMed:10586065, PubMed:11432818, PubMed:21081917). Interacts with host TCR alpha-chain TRAV27 (PubMed:17709482, PubMed:21081917)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1ENF | X-ray | 1.69 Å | A=26-237 |
| 1EWC | X-ray | 1.95 Å | A=26-239 |
| 2XNA | X-ray | 2.1 Å | C=25-241 |
| 2XN9 | X-ray | 2.3 Å | C=25-241 |
| 1F77 | X-ray | 2.4 Å | A/B=25-241 |
| 1HXY | X-ray | 2.6 Å | D=25-237 |
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