Large ribosomal subunit protein bL12 (rplL) is a 121-residue protein from Escherichia coli (strain K12). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0A7K2.
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The mean pLDDT of this model is 77.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 60% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
The binding site for several of the GTPase factors involved in protein synthesis (IF-2, EF-Tu, EF-G and RF3). Is thus essential for accurate translation. Deletion of 1 of the L12 dimers from the ribosome (by deleting the binding site on L10) leads to decreased IF-2 association with the 70S ribosome and decreased stimulation of the GTPase activity of EF-G
Homodimer. Part of the 50S ribosomal subunit; present in 4 copies per ribosome. L7/L12 forms dimers with an elongated shape. Two dimers associate with a copy of L10 to form part of the ribosomal stalk (called L8). The ribosomal stalk helps the ribosome interact with GTP-bound translation factors. Forms a pentameric L10(L12)2(L12)2 complex, where L10 forms an elongated spine to which 2 L12 dimers…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1CTF | X-ray | 1.7 Å | A=48-121 |
| 7N2C | EM | 2.72 Å | LG=1-121 |
| 4V9O | X-ray | 2.9 Å | A6=1-121 |
| 6X7K | EM | 3.1 Å | Z=1-121 |
| 8URY | EM | 3.1 Å | Z=1-121 |
| 4V85 | X-ray | 3.2 Å | BJ/BK/BL/BM=1-121 |
| 6I0Y | EM | 3.2 Å | 6=1-121 |
| 6X6T | EM | 3.2 Å | Z=1-121 |
| 8UQL | EM | 3.2 Å | Z=1-121 |
| 8UR0 | EM | 3.4 Å | Z=1-121 |
| 8VOO | EM | 3.4 Å | Z=1-121 |
| 6X7F | EM | 3.5 Å | Z=1-121 |
| 8VKV | EM | 3.6 Å | Z=1-121 |
| 8VOR | EM | 3.6 Å | Z=1-121 |
| 8PHJ | EM | 3.67 Å | W=2-121 |
| 4V89 | X-ray | 3.7 Å | BJ/BK/BL/BM=1-121 |
| 6VU3 | EM | 3.7 Å | Z=2-31 |
| 6VYQ | EM | 3.7 Å | Z=1-121 |
| 6VYS | EM | 3.7 Å | Z=1-121 |
| 6XDQ | EM | 3.7 Å | Z=1-121 |
Showing 20 of 58 experimental structures (best resolution first).
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