Alpha-conotoxin RgIA is a 32-residue protein from Conus regius. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P0C1D0.
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The mean pLDDT of this model is 77.2 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 88% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
This toxin target two types of receptors, the nicotinic acetylcholine receptor (nAChR) and the G protein-coupled receptor GABA(B). It specifically inhibits the alpha-9-alpha-10/CHRNA9-CHRNA10 nAChR, with preference for rat receptors (PubMed:16445293, PubMed:18242183, PubMed:18295795, PubMed:21888386, PubMed:22774872, PubMed:25740413, PubMed:28223528). It interacts with the alpha-10(+)/alpha-9(-)interface of the receptor (PubMed:25740413). It shows a two order of magnitude species difference potency for the rat versus human alpha-9-alpha-10 nAChR, due to the Thr-86 located in the alpha-9 nAChR subunit (PubMed:22774872). This toxin also shows inhibition of high voltage-activated (HVA)…
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HY7 | X-ray | 2.26 Å | B=20-32 |
| 7EGR | X-ray | 2.5 Å | K/L/M/N/O/P/Q/R=20-32 |
| 2JUQ | NMR | A=20-32 | |
| 2JUR | NMR | A=20-32 | |
| 2JUS | NMR | A=20-32 | |
| 2JUT | NMR | A=20-32 | |
| 2MTO | NMR | A=20-32 | |
| 2MTT | NMR | A=20-32 | |
| 8W16 | NMR | A=19-32 | |
| 8W17 | NMR | A=19-32 |
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